Overexpression of CCNE1 confers a poorer prognosis in triple-negative breast cancer identified by bioinformatic analysis

Overexpression of CCNE1 confers a poorer prognosis in triple-negative breast cancer identified by bioinformatic analysis

March 29, 2021 Off By Ava Banks
Triple-negative breast cancer (TNBC) is a main subtype of breast cancer. Due to the dearth of efficient therapeutic targets, the prognosis is poor. In order to seek out an efficient goal, regardless of many efforts, the molecular mechanisms of TNBC are nonetheless not nicely understood which stay to be a profound scientific problem. To establish the candidate genes in the carcinogenesis and development of TNBC, microarray datasets GSE36693 and GSE65216 had been downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) had been identified, and purposeful and pathway enrichment analyses had been carried out utilizing the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases by way of DAVID.
We constructed the protein-protein interplay community (PPI) and carried out the module analysis utilizing STRING and Cytoscape. Then, we reanalyzed the chosen DEG genes, and the survival analysis was carried out utilizing cBioportal. A complete of 140 DEGs had been identified, consisting of 69 upregulated genes and 71 downregulated genes. Three hub genes had been upregulated among the many chosen genes from PPI, and organic course of analysis uncovered the truth that these genes had been primarily enriched in p53 pathway and the pathways in cancer. Survival analysis confirmed that solely CCNE1 could also be concerned in the carcinogenesis, invasion, or recurrence of TNBC.
The expression ranges of CCNE1 had been considerably greater in TNBC cells than non-TNBC cells that had been detected by qRT-PCR (P < 0.05). CCNE1 may confer a poorer prognosis in TNBC identified by bioinformatic analysis and performs key roles in the development of TNBC which can contribute potential targets for the prognosis, therapy, and prognosis evaluation of TNBC. This research goals to establish pathway involvement in the event of cisplatin (cis-diamminedichloroplatinum (II); CDDP) resistance in A549 lung cancer (LC) cells by using superior bioinformatics software program. We developed CDDP-resistant A549 (A549/DDP) cells via extended incubation with the drug and carried out RNA-seq on RNA extracts to find out differential mRNA and miRNA expression between A549/DDP and A549 cells.
We analyzed the gene dysregulation with Ingenuity Pathway Analysis (IPA; QIAGEN) software program. In distinction to prior analysis, which relied on the clustering of dysregulated genes to pathways as a sign of pathway exercise, we utilized the IPA software program for the dynamic analysis of pathway exercise relying on the gene dysregulation ranges. We predicted 15 pathways considerably contributing to the chemoresistance, with a number of of them to haven’t been beforehand reported or analyzed in element.

GPRC5A: An rising prognostic biomarker for predicting malignancy of Pancreatic Cancer based mostly on bioinformatics analysis

Pancreatic cancer (PaCa) is a extremely deadly malignancy. The therapy choices for PaCa lack efficacy. The research aimed to discover the molecular biomarkers for predicting survival of PaCa and establish the potential carcinogenic mechanisms of the chosen gene. Based on public databases of PaCa, differentially expressed genes (DEGs) had been identified utilizing Networkanalyst. Survival analyses had been exerted on GEPIA. Oncomine and The Human Protein Atlas had been used for verifying the expression on mRNA and protein ranges. Enrichment analyses had been generated on Metascape and gene set enrichment analysis (GSEA).

Univariate analyses had been carried out to find out the scientific components related to the expression of GPRC5A. GPRC5A was identified as essentially the most useful gene in predicting survival of PaCa sufferers. Patients with excessive expression of GPRC5A confirmed bigger tumor measurement, greater TNM levels, greater tumor grade, and extra constructive resection margin. In mutant KRAS, TP53, CDKN2A and SMAD4 group, the expression of GPRC5A was greater than non-mutant group.

Mechanistically, GPRC5A might promote metastasis of PaCa primarily by way of regulating epithelial-mesenchymal transition (EMT) and neuroactive ligand-receptor interplay. GPRC5A might act as an oncogene in the development of PaCa and could possibly be a prognostic biomarker in predicting survival of PaCa.  Among them, the PKR signaling, ldl cholesterol biosynthesis, and TEC signaling pathways are included, in addition to genes, reminiscent of PIK3R3, miR-34c-5p, and MDM2, amongst others. We additionally present a preliminary analysis of SNPs and indels, current solely in A549/DDP cells. This research’s outcomes present novel potential mechanisms and molecular targets that may be explored in future research and help in enhancing the understanding of the chemoresistance phenotype.

Overexpression of CCNE1 confers a poorer prognosis in triple-negative breast cancer identified by bioinformatic analysis

Bioinformatic analysis for the identification of potential gene interactions and therapeutic targets in atrial fibrillation

Atrial fibrillation (AF) is the most typical kind of tachycardia. The main harm induced by AF is a systemic embolism. Although AF therapies have advanced considerably, the success charge of sinus rhythm upkeep is comparatively low. The purpose is the unfinished understanding of the AF mechanisms. A Gene Expression Omnibus (GEO) dataset (GSE79768) was downloaded. Differentially expressed genes (DEGs) had been identified by bioinformatic analysis. Enriched phrases and pathways had been identified by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses.
A protein-protein interplay (PPI) community was constructed to find out regulatory genes. CytoHubba and the Molecular Complex Detection (MCODE) algorithm had been used to establish potential hub genes and necessary modules. The Predicting Associated Transcription Factors From Annotated Affinities (PASTAA) technique was used to foretell transcription components (TFs). Two hundred thirty-five upregulated DEGs and seventy-seven downregulated DEGs had been identified. In the GO organic course of, mobile element, and molecular operate analyses, constructive regulation of cell migration, anchoring junctions, and cell adhesion molecule binding had been enriched considerably. The Hippo signalling pathway was essentially the most considerably enriched pathway.

Coomassie brilliant blue R-250

20-abx082400
  • EUR 230.00
  • EUR 189.00
  • 25 g
  • 5 g
  • Shipped within 5-10 working days.

Coomassie brilliant blue R-250

20-abx082561
  • EUR 217.00
  • EUR 175.00
  • 25 g
  • 5 g
  • Shipped within 5-10 working days.

Coomassie Brilliant Blue R-250

CH026 50 g
EUR 175

Coomassie brilliant blue R-250

CB0037 5g
EUR 58.7
  • Product category: Biochemicals/Indicators/Stains/Peptide/Protein Related

Coomassie brilliant blue R-250 2 xSolution

C462151 250ml
EUR 106.55
  • Product category: Biochemicals/Indicators/Stains/Peptide/Protein Related

Brilliant Blue G

C5579-100000 100 g
EUR 135
Description: Coomassie Brilliant Blue G-250 is used for protein staining in SDS-PAGE, Blue Native PAGE, and the Bradford Method, with high band visibility.

Brilliant Blue FCF

HY-D0915 500mg
EUR 108

Coomassie Brilliant Blue G250

abx090654-5g 5 g
EUR 189
  • Shipped within 5-10 working days.

Coomassie Brilliant Blue R250

abx090655-5g 5 g
EUR 189
  • Shipped within 5-10 working days.

OPTIONAL BLUE FILTER (497NM)

GDBL-BLUE 1/pk
EUR 1082
Description: Lab Equipment; Axygen Branded EQ

conversion screen uv/blue

VLFC26-BLUE ea
EUR 606

Brilliant Cresyl Blue (0.3%, Alcoholic)

BCA3800 1 Gal.
EUR 241

Brilliant Cresyl Blue (0.3%, Alcoholic)

BCA500 500 ml
EUR 90

Brilliant Cresyl Blue (0.3%, Alcoholic)

BCA999 1000 ml
EUR 116

Brilliant Cresyl Blue (C.I. 51010)

GT9275-10G 10 g
EUR 86

Brilliant Cresyl Blue (C.I. 51010)

GT9275-25G 25 g
EUR 110

Coomassie brilliant blue G-250

20-abx082402
  • EUR 230.00
  • EUR 189.00
  • 25 g
  • 5 g
  • Shipped within 5-10 working days.

Coomassie brilliant blue G-250

20-abx082562
  • EUR 217.00
  • EUR 175.00
  • 25 g
  • 5 g
  • Shipped within 5-10 working days.

Coomassie brilliant blue G-250

CB0038 25g
EUR 75.23
  • Product category: Biochemicals/Indicators/Stains/Peptide/Protein Related

Coomassie Brilliant Blue G250 (C.I. 42655)

GT0353-100G 100 g
EUR 126

Coomassie Brilliant Blue G250 (C.I. 42655)

GT0353-25G 25 g
EUR 62

Coomassie Brilliant Blue G250 (C.I. 42655)

GT0353-5G 5 g
EUR 46

Coomassie Brilliant Blue R250 (C.I. 42660)

GT3543-100G 100 g
EUR 126

Coomassie Brilliant Blue R250 (C.I. 42660)

GT3543-25G 25 g
EUR 62

Coomassie Brilliant Blue R250 (C.I. 42660)

GT3543-5G 5 g
EUR 46

Coomassie Brilliant Blue Fast Staining Solution

abx090652-200ml 200 ml
EUR 203
  • Shipped within 5-10 working days.

Coomassie Brilliant Blue Gel Staining Kit

abx090653-1Kit 1 Kit
EUR 189
  • Shipped within 5-10 working days.

Brilliant Cresyl Blue (1.5% in 0.85% Saline)

BCS3800 1 Gal.
EUR 241

Brilliant Cresyl Blue (1.5% in 0.85% Saline)

BCS500 500 ml
EUR 90

Brilliant Cresyl Blue (1.5% in 0.85% Saline)

BCS999 1000 ml
EUR 116

10G Coomassie Blue R-250

NAT1360 10G
EUR 103

1000UL BLUE TIPS, RACKED AND PRE-STERILIZED

T-1000-B-R-S 1000/pk
EUR 175
Description: Non Filter Tips; Pipette Tips - Axygen

1000UL BLUE TIPS COMPATIBLE WITH EPPENDORF AND SOCOREX PIPETTORS.

TE-1004-B-R 1152/pk
EUR 212
Description: Non Filter Tips; Pipette Tips - Axygen

Fluorescence Microscopy Aid

4400 3 ml
EUR 180.5
Description: This is Counter - Stain/Blocking Diluent with optimal formula for preparaiton of final dilutions of FITC conjugate prior to use in FA procedures.

Brilliant green

BB0242 25g
EUR 56.09
  • Product category: Biochemicals/Indicators/Stains/Biological Stains

Holder for Plasmid Midi, Maxi and Maxi plus, Ion Exchange column

FAPDE-holder-for-ion-exchange 1 prep
EUR 158

1000UL MAXYMUM RECOVERY BLUE TIPS COMPATIBLE WITH EPPENDORF AND SOCOREX PIPETTORS.

TE-1004-B-L-R 1152/pk
EUR 219
Description: Non Filter Tips; Maxymum Recovery Pipette Tips - Axygen

1000UL PRE-STERILIZED BLUE TIPS COMPATIBLE WITH EPPENDORF AND SOCOREX PIPETTORS

TE-1004-B-R-S 1152/pk
EUR 231
Description: Non Filter Tips; Pipette Tips - Axygen

Human tenascin-R(TN-R)ELISA Kit

QY-E00282 96T
EUR 361

Rat tenascin-R(TN-R)ELISA Kit

QY-E10465 96T
EUR 361

Mouse tenascin-R(TN-R)ELISA Kit

QY-E21437 96T
EUR 361

1000UL BLUE TIPS, RACKED

T-1000-B-R 1000/pk
EUR 161
Description: Non Filter Tips; Pipette Tips - Axygen

BRILLIANT GREEN AGAR

B02-115-10kg 10 kg
EUR 1222

BRILLIANT GREEN AGAR

B02-115-2Kg 2 Kg
EUR 305

BRILLIANT GREEN AGAR

B02-115-500g 500 g
EUR 119

1000UL MAXYMUM RECOVERY BLUE TIPS COMPATIBLE WITH EPPENDORF AND SOCOREX PIPETTORS.

TE-1004-B-L-R-S 1152/pk
EUR 239
Description: Non Filter Tips; Maxymum Recovery Pipette Tips - Axygen

Blue Base for Dissecting Board

M625 1 ea.
EUR 200

Blue ear pig virus ELISA Kit -

QY-E40015 96T
EUR 394

BRILLIANT GREEN BILE AGAR

B02-122-10kg 10 kg
EUR 1267

BRILLIANT GREEN BILE AGAR

B02-122-2Kg 2 Kg
EUR 315

BRILLIANT GREEN BILE AGAR

B02-122-500g 500 g
EUR 122

Brilliant Green (C.I. 42040)

GT6123-100G 100 g
EUR 78

Brilliant Green (C.I. 42040)

GT6123-25G 25 g
EUR 46

Brilliant Crocein (C.I. 27290)

GT8393-100G 100 g
EUR 86

Brilliant Crocein (C.I. 27290)

GT8393-250G 250 g
EUR 150

Brilliant Crocein (C.I. 27290)

GT8393-50G 50 g
EUR 62

Rat Creatine kinase for muscle and brain (CKMB)

QY-E11888 96T
EUR 374

ECOS Blue (XL1-Blue

FYE107-10VL 100 µl x 10 vials Ask for price

ECOS Blue (XL1-Blue

FYE107-80VL 100 µl x 10 vials Ask for price

ECOS Blue (XL1-Blue

FYE108-10VL 100 µl x 10 vials Ask for price

ECOS Blue (XL1-Blue

FYE108-80VL 100 µl x 10 vials Ask for price

ECOS Blue (XL1-Blue

FYE109-10VL 100 µl x 10 vials Ask for price

ECOS Blue (XL1-Blue

FYE109-80VL 100 µl x 10 vials Ask for price

4-Ways Microtube and Centrifuge Tubes Racks, Blue

R023-B 1 UNIT
EUR 53.48
  • Product category: Labware/Tube Racks/Multipurpose

BRILLIANT GREEN AGAR WITH SULFAPYRIDINE

B02-117-10kg 10 kg Ask for price

BRILLIANT GREEN AGAR WITH SULFAPYRIDINE

B02-117-2kg 2kg Ask for price

BRILLIANT GREEN AGAR WITH SULFAPYRIDINE

B02-117-500g 500 g Ask for price

BRILLIANT GREEN BILE BROTH 2%

B02-118-10kg 10 kg
EUR 1022

BRILLIANT GREEN BILE BROTH 2%

B02-118-2Kg 2 Kg
EUR 261

BRILLIANT GREEN BILE BROTH 2%

B02-118-500g 500 g
EUR 107

Brilliant Black BN (C.I. 28440)

GT6953-100G 100 g
EUR 140

Brilliant Black BN (C.I. 28440)

GT6953-10G 10 g
EUR 54

Brilliant Black BN (C.I. 28440)

GT6953-25G 25 g
EUR 78

Cibacron Brilliant Red 3B-A

GT9393-25G 25 g
EUR 181

Cibacron Brilliant Red 3B-A

GT9393-5G 5 g
EUR 78

Power leads for HorizeBLOT-R

2322462 5unit
EUR 270

Monoclonal antibody for Ankyrin R

SMC-487D 0.1mg
EUR 353
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is not conjugated.

Monoclonal antibody for Ankyrin R

SMC-487D-A390 0.1mg
EUR 400
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with ATTO 390.

Monoclonal antibody for Ankyrin R

SMC-487D-A488 0.1mg
EUR 399
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with ATTO 488.

Monoclonal antibody for Ankyrin R

SMC-487D-A565 0.1mg
EUR 399
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with ATTO 565.

Monoclonal antibody for Ankyrin R

SMC-487D-A594 0.1mg
EUR 399
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with ATTO 594.

Monoclonal antibody for Ankyrin R

SMC-487D-A633 0.1mg
EUR 399
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with ATTO 633.

Monoclonal antibody for Ankyrin R

SMC-487D-A655 0.1mg
EUR 399
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with ATTO 655.

Monoclonal antibody for Ankyrin R

SMC-487D-A680 0.1mg
EUR 399
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with ATTO 680.

Monoclonal antibody for Ankyrin R

SMC-487D-A700 0.1mg
EUR 399
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with ATTO 700.

Monoclonal antibody for Ankyrin R

SMC-487D-ALP 0.1mg
EUR 393
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with Alkaline Phosphatase.

Monoclonal antibody for Ankyrin R

SMC-487D-APC 0.1mg
EUR 398
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with APC.

Monoclonal antibody for Ankyrin R

SMC-487D-APCCY7 0.1mg
EUR 470
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with APC/Cy7.

Monoclonal antibody for Ankyrin R

SMC-487D-BI 0.1mg
EUR 395
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with Biotin.

Monoclonal antibody for Ankyrin R

SMC-487D-DY350 0.1mg
EUR 413
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with Dylight 350.

Monoclonal antibody for Ankyrin R

SMC-487D-DY405 0.1mg
EUR 402
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with Dylight 405.

Monoclonal antibody for Ankyrin R

SMC-487D-DY488 0.1mg
EUR 392
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with Dylight 488.

Monoclonal antibody for Ankyrin R

SMC-487D-DY594 0.1mg
EUR 394
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with Dylight 594.

Monoclonal antibody for Ankyrin R

SMC-487D-DY633 0.1mg
EUR 389
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with Dylight 633.

Monoclonal antibody for Ankyrin R

SMC-487D-FITC 0.1mg
EUR 391
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with FITC.

Monoclonal antibody for Ankyrin R

SMC-487D-HRP 0.1mg
EUR 387
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with HRP.

Monoclonal antibody for Ankyrin R

SMC-487D-P594 0.1mg
EUR 406
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with PE/ATTO 594.

Monoclonal antibody for Ankyrin R

SMC-487D-PCP 0.1mg
EUR 398
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with PerCP.

Monoclonal antibody for Ankyrin R

SMC-487D-RPE 0.1mg
EUR 396
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with RPE.

Monoclonal antibody for Ankyrin R

SMC-487D-STR 0.1mg
EUR 397
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is conjugated with Streptavidin.

Monoclonal antibody for Ankyrin R

SMC-487S 0.012mg
EUR 65
  • Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral m
  • Show more
Description: A monoclonal antibody from clone S388A-10 against Human Ankyrin R. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R. The antibody is tested and validated for WB, IHC, ICC/IF assays with the following recommended dilutions: WB (1:1000). This MAb for Ankyrin R is not conjugated.

EMPTY REFILL RACK WITH LID FOR USE WITH P2/P10 GILSON-STYLE AND 200UL UNIVERSAL FIT INSERTS.

RFL-R 10/pk
EUR 93
Description: Non Filter Tips; Pipette Tips - Axygen

20UL CLEAR TIPS FOR PACKARDS PLATE TRACK, EVOLUTION AND MINI TRACK INSTRUMENTS.

PK-20-R 960/pk
EUR 252
Description: Robotic Tips; Robotic tips - Axygen

200UL CLEAR TIPS FOR PACKARDS PLATE TRACK, EVOLUTION AND MINI TRACK INSTRUMENTS.

PK-200-R 960/pk
EUR 285
Description: Robotic Tips; Robotic tips - Axygen

50UL CLEAR TIPS FOR PACKARDS PLATE TRACK, EVOLUTION AND MINI TRACK INSTRUMENTS.

PK-50-R 960/pk
EUR 249
Description: Robotic Tips; Robotic tips - Axygen

Human Tenascin R(TNR)ELISA Kit

QY-E03056 96T
EUR 361

ELISA kit for Human R-type pyruvate kinase (R-PK)

KTE62579-48T 48T
EUR 354
  • The protein encoded by R-PK is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocyti
  • Show more
Description: Quantitative sandwich ELISA for measuring Human R-type pyruvate kinase (R-PK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human R-type pyruvate kinase (R-PK)

KTE62579-5platesof96wells 5 plates of 96 wells
EUR 2252
  • The protein encoded by R-PK is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocyti
  • Show more
Description: Quantitative sandwich ELISA for measuring Human R-type pyruvate kinase (R-PK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human R-type pyruvate kinase (R-PK)

KTE62579-96T 96T
EUR 572
  • The protein encoded by R-PK is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocyti
  • Show more
Description: Quantitative sandwich ELISA for measuring Human R-type pyruvate kinase (R-PK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human Protein Kinase R(PKR)ELISA Kit

QY-E03858 96T
EUR 361

Human R-Spondin 3(RSPO3)ELISA Kit

QY-E04633 96T
EUR 361

Human R-Spondin 2(RSPO2)ELISA Kit

QY-E04634 96T
EUR 361

Human R-Spondin 1(RSPO1)ELISA Kit

QY-E04635 96T
EUR 361

(R,R)-THC

B6909-10 10 mg
EUR 583

(R,R)-Hymeglusin

B1244-1000
EUR 479

(R,R)-Hymeglusin

B1244-500
EUR 294

(R,R)-Dipamp

20-abx181460
  • EUR 690.00
  • EUR 370.00
  • 1 g
  • 250 mg
  • Shipped within 1-2 weeks.

R-S-R

5-01865 4 x 5mg Ask for price

0.5-10UL CLEAR TIPS FOR P2/P10, RACKED AND PRE-STERILIZED

T-300-R-S 960/pk
EUR 135
Description: Non Filter Tips; Pipette Tips - Axygen

1.5 AND 2.0ML PRE-STERILIZED INDIVIDUALLY WRAPPED BLUE PESTLE

PES-15-B-SI 100/pk
EUR 177
Description: Micro Tubes; Micro Tubes Push Cap- Axygen

1000UL BLUE TIPS COMPATIBLE WITH EPPENDORF AND SOCOREX PIPETTORS

TE-1004-B 500/pk
EUR 126
Description: Non Filter Tips; Pipette Tips - Axygen

Inoculating Loops and Needles, 1ul Blue, Sterile, 25/Bag

IL311-1 1PK, 25UNIT
EUR 51.62
  • Product category: Labware/Culture Related/Inoculating Loops/Needles

80 WELL RED MICROTUBE RACK FOR 1.5/2.0ML MICROTUBES

R-80-R 5/pk
EUR 94
Description: Micro Tubes; Racks Tubes - Axygen

4-Ways Microtube and Centrifuge Tubes Racks, Red

R023-R 1 UNIT
EUR 53.48
  • Product category: Labware/Tube Racks/Multipurpose

Bromophenol Blue

B7774-5000 5 g
EUR 87
Description: IC50: N/ABromophenol blue (3',3",5',5"-tetrabromophenolsulfonphthalein) is widely used in gel loading buffers. Bromophenol blue is experimentally used as acolor marker, apH indicator, and a dye.

Calcein Blue

HY-101887 25mg
EUR 119

Thiazolyl Blue

HY-15924 10mM/1mL
EUR 113

Evans Blue

HY-B1102 100mg
EUR 119

Bromothymol Blue

HY-D0012 1g
EUR 119

Diphenyl Blue

HY-D0970 10mM/1mL
EUR 113

Methylene Blue

HY-14536 100mg
EUR 119

Meldola's blue

GT0259-10G 10 g
EUR 86

Meldola's blue

GT0259-25G 25 g
EUR 134

Meldola's blue

GT0259-50G 50 g
EUR 213

Bromochlorophenol Blue

GT2674-100MG 100 mg
EUR 78

Bromochlorophenol Blue

GT2674-1G 1 g
EUR 174

Bromophenol Blue

GT2874-100G 100 g
EUR 126

Bromophenol Blue

GT2874-10G 10 g
EUR 52

Bromophenol Blue

GT2874-25G 25 g
EUR 66

Bromophenol Blue

GT2874-50G 50 g
EUR 86

Bromophenol Blue

GT2874-5G 5 g
EUR 45

Hydroxynaphthol blue

GT3182-100G 100 g
EUR 237

Hydroxynaphthol blue

GT3182-10G 10 g
EUR 78

Hydroxynaphthol blue

GT3182-25G 25 g
EUR 110

Hydroxynaphthol blue

GT3182-50G 50 g
EUR 166

Bromothymol Blue

GT6837-10G 10 g
EUR 47

Bromothymol Blue

GT6837-25G 25 g
EUR 61

Bromothymol Blue

GT6837-50G 50 g
EUR 86

Bromothymol Blue

GT6837-5G 5 g
EUR 42

Xylenol Blue

GT7988-1G 1 g
EUR 46
In the PPI community analysis, we discovered that Class A/1 (rhodopsin-like receptors) could be the vital module. Ten hub genes had been extracted, together with 6 upregulated genes and four downregulated genes. CXCR2, TLR4, and CXCR4 might play vital roles in AF. In the TF prediction, we discovered that Irf-1 could also be implicated in AF. We discovered that the CXCR4, TLR4, CXCR2 genes, the Hippo signalling pathway and the category A/1 (rhodopsin-like receptors) module might play vital roles in AF incidence and upkeep, which can present novel targets for AF therapy.