Cancer is a risk to human well being, and lots of molecules are concerned in the transformation of malignant cells. Hepatocyte nuclear issue 1A (HNF1A) is a vital transcription issue that regulates a number of organic processes. Our analysis centered on elucidating the expression and performance of HNF1A in most cancers by means of bioinformatic analysis. UALCAN, Kaplan-Meier plotter, COSMIC, Tumor IMmune Estimation Resource, and Cancer Regulome have been used to acquire related information for HNF1A. HNF1A was abnormally expressed in a number of cancers, and its expression was related to variations in total survival in sufferers with most cancers. HNF1A mutations extensively exist in tumors and work together with totally different genes concerned in varied processes.
Additionally, we discovered that HNF1A was related to the infiltration of immune cells, and it affected the prognostic worth of these cells in some cancers. HNF1A performs a vital position in most cancers, and it could symbolize a biomarker and goal for future most cancers immunotherapy. Diabetes mellitus erectile dysfunction (DMED) is a frequent complication of diabetes. Mesenchymal stem cell (MSC) remedy was demonstrated to enhance erectile operate in DMED. However, the pathogenesis of DMED and the mechanism by which MSCs operate are nonetheless unclear.
We established a rat mannequin of DMED and gave MSC remedy by means of intracavernous injection. After transcriptome sequencing of rats’ penile tissue, we recognized a complete of 1,097 overlapped differentially expressed genes (DEGs) of the conventional management group, DMED group, and MSC-treated group, containing 189 upregulated genes and 908 downregulated genes. The enriched features of upregulated DEGs included extracellular matrix organisation (GO:0030198), extracellular construction organisation (GO:0043062), and wound therapeutic (GO:0042060), PPAR signalling pathway (rno03320), arachidonic acid metabolism (rno00590) and retinol metabolism (rno00830).
Superoxide dismutase (SOD) as a range criterion for triticale grain yield beneath drought stress: a complete examine on genomics and expression profiling, bioinformatics, heritability, and phenotypic variability
The predominant goals of this examine have been to search out the attainable structural affiliation between the exercise of enzymatic antioxidants and the grain yield of triticale crops in addition to figuring out the genotypic variability which could be efficient on this affiliation. Accordingly, expression ranges of superoxide dismutase (SOD) isozymes (Mn-SOD, Cu/Zn-SOD, and Fe-SOD) have been appraised to differentiate any attainable relationship between SOD expression and drought resistance of triticale. A novel analytical technique for distinguishing elite genotypes based mostly on measured options was proposed.
Additionally, a brand new programing based mostly on SAS-language (IML) was launched to estimate the genetic parameters rooted from mixed ANOVA mannequin (linear combined mannequin), which is succesful of getting used in any subject examine aside from the present one. Thirty genotypes of triticale have been studied beneath regular and drought stress situations throughout 6 years (three totally different areas). Accordingly, based mostly on the outcomes of genetic variability, heatmap analysis, biplot graph, and clustering method, two genotypes with the best genetic distance have been chosen to appraise the differential expression profiling of three SOD isozyme in shoot and root organs.
Additionally, Mn-SOD and Fe-SOD confirmed roughly comparable expression ranges for each genotypes beneath drought stress. However, Cu/Zn-SOD expression degree was increased in root and shoot of the tolerant genotype than the prone genotype. Heatmap analysis that’s utilized for the primary time to display screen appropriate genotypes, confirmed to be extremely succesful of distinguishing elite genotypes and stating the right options for choice standards. Bioinformatics outcomes indicated that SOD is extra vital than different enzymatic antioxidant for being thought-about as choice standards or candidate gene for transgenic functions.
Based on expressional outcomes, Mn-SOD introduced as a common isozyme that’s in all probability extremely expressed in most of the species, whereas, Cu/Zn-SOD was launched as a genotype particular isozyme that’s possible extra expressed in tolerant genotypes. Field experiments and bioinformatics outcomes confirmed that superoxide dismutase (SOD) was probably the most influential antioxidant in resistance of triticale to drought stress; subsequently, it may very well be used as an oblique choice index in early phases to differentiate resistant genotypes to drought stress.
Bioinformatic analysis of chromatin group and biased expression of duplicated genes between two poplars with a standard whole-genome duplication
The nonrandom three-dimensional group of chromatin performs an vital position in the regulation of gene expression. However, it stays unclear whether or not this group is conserved and whether or not it’s concerned in regulating gene expression throughout speciation after whole-genome duplication (WGD) in crops. In this examine, high-resolution interplay maps have been generated utilizing high-throughput chromatin conformation seize (Hi-C) strategies for 2 poplar species, Populus euphratica and Populus alba var. pyramidalis, which diverged ~14 Mya after a standard WGD.
We examined the similarities and variations in the hierarchical chromatin group between the 2 species, together with A/B compartment areas and topologically associating domains (TADs), in addition to in their DNA methylation and gene expression patterns. We discovered that chromatin standing was strongly related to Major depressive dysfunction (MDD) is a extremely prevalent illness and one of the primary causes of incapacity worldwide. Although many research have partially revealed the prevalence and improvement course of of MDD, the pathogeny and molecular mechanisms will not be absolutely understood.
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1000 ml |
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Description: Sample Diluent Buffer by Cygnus Technologies is available in Europe via Gentaur. |
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I028-500 |
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500 ml |
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Arbor Assays |
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F223A |
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F183A |
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1000 ml |
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500 ml |
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Description: SP2/0 Sample Diluent by Cygnus Technologies is available in Europe via Gentaur. |
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F213A |
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1000 ml |
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Description: Goat IgG Sample Diluent by Cygnus Technologies is available in Europe via Gentaur. |
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F213A-100 |
Cygnus Technologies |
100 ml |
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Description: Goat IgG Sample Diluent by Cygnus Technologies is available in Europe via Gentaur. |
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F213A-500 |
Cygnus Technologies |
500 ml |
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Description: Goat IgG Sample Diluent by Cygnus Technologies is available in Europe via Gentaur. |
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RM00023 |
Abclonal |
20mL |
EUR 280 |
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Arbor Assays |
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Cygnus Technologies |
25 ml |
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SDB-025 |
BioAssayWorks |
25 mL |
EUR 83.7 |
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Cygnus Technologies |
100 ml |
EUR 308.4 |
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Description: Mix-N-Go Sample Diluent, 100mL by Cygnus Technologies is available in Europe via Gentaur. |
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DPGDAB-100mL |
Diagnopal |
100 mL |
EUR 59.28 |
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DPGDAB-1Liter |
Diagnopal |
1 Liter |
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F243A |
Cygnus Technologies |
1000 ml |
EUR 678 |
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Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur. |
Goat Milk Proteins Sample Diluent |
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F243A-100 |
Cygnus Technologies |
100 ml |
EUR 308.4 |
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Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur. |
Goat Milk Proteins Sample Diluent |
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F243A-500 |
Cygnus Technologies |
500 ml |
EUR 493.2 |
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Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur. |
 Standard and Sample Diluent Buffer |
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abx092103-20ml |
Abbexa |
20 ml |
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 General Purpose Sample Diluent-SD1 |
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KF17352 |
Neuromics |
500 ml |
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IMS0514 |
ImmunoStep |
10 |
EUR 55 |
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Description: Sample diluent buffer (1X) |
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DPGDAB-10X-100mL |
Diagnopal |
100 mL |
EUR 159.6 |
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DPGDAB-10X-1Liter |
Diagnopal |
1 Liter |
EUR 1223.6 |
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694 |
Immunochemistry |
100 mL |
EUR 57.25 |
Plasma Sample Diluent (Antigen-Down SD) |
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695 |
Immunochemistry |
500 mL |
EUR 227.5 |
-SD2) Plasma Sample Diluent (Antigen-Down)-SD2 |
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KF17353 |
Neuromics |
500 ml |
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 ANTIGEN DOWN PLASMA SAMPLE DILUENT Reagent |
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GWB-Q00209 |
GenWay Biotech |
100 ml |
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ANTIGEN DOWN PLASMA SAMPLE DILUENT Reagent |
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GWB-Q00210 |
GenWay Biotech |
1000 ml |
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 Low NSB Sample Diluent for ELISA Kit, ready to use |
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LNSB-30 |
Alpha Diagnostics |
30 ml |
EUR 196.8 |
Low NSB Sample Diluent for ELISA Kit, ready to use |
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LNSB-500 |
Alpha Diagnostics |
500 ml |
EUR 790.8 |
 Sample Diluent Optimization Pack: 100mL SD1, SD2, SD3, PFSD |
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959 |
Immunochemistry |
pack |
EUR 187 |
 All Sample Diluents Sample Pack |
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KF17355 |
Neuromics |
3X100 ml |
EUR 326.4 |
 OOSA09671-1L - ANTIGEN DOWN PLASMA SAMPLE DILUENT Accessory Reagent |
|
OOSA09671-1L |
Aviva Systems Biology |
1000ml |
EUR 669 |
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 OOSA11219-100ML - ANTIGEN DOWN PLASMA SAMPLE DILUENT Accessory Reagent |
|
OOSA11219-100ML |
Aviva Systems Biology |
100ml |
EUR 169 |
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 for ELISA (For serum, plasma sample conservation and low background)) Sample, Antibody and Conjugate Diluent (20X) for ELISA (For serum, plasma sample conservation and low background) |
|
80066 |
Alpha Diagnostics |
50 ml |
EUR 278.4 |
 All Assay Diluents Sample Pack |
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KF17351 |
Neuromics |
4X100 ml |
EUR 326.4 |
 sample/Conjugate Diluent (Green) for ELISA (antibody assay) concentrate (10X)) Whole egg yolk (IgY) sample/Conjugate Diluent (Green) for ELISA (antibody assay) concentrate (10X) |
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80071 |
Alpha Diagnostics |
50 ml |
EUR 242.4 |
 Neptune 1000ul barrier tip |
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BT1000.96 |
Biotix |
8 trays of 96 / pack |
EUR 70.8 |
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Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface |
 Neptune 300ul barrier tip |
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BT300 |
Biotix |
10 trays of 96 / pack |
EUR 70.8 |
|
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface |
 Neptune 100ul barrier tip |
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BT100 |
Biotix |
10 trays of 96 / pack |
EUR 70.8 |
|
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface |
 Neptune 200ul barrier tip |
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BT200 |
Biotix |
10 trays of 96 / pack |
EUR 70.8 |
|
Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface |
 Neptune 1000-1250ul barrier tip |
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BT1250 |
Biotix |
8 trays of 96 / pack |
EUR 70.8 |
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Description: Extended Length, Low retention, Racked, Pre-Sterile, Sample Saving Surface |
 Neptune 10ul barrier tip |
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BT10 |
Biotix |
10 trays of 96 / pack |
EUR 70.8 |
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Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface |
 Neptune 20ul barrier tip |
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BT20 |
Biotix |
10 trays of 96 / pack |
EUR 70.8 |
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Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface |
 ELISA NEPTUNE BUFFER Reagent |
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GWB-Q00221 |
GenWay Biotech |
100 ml |
Ask for price |
ELISA NEPTUNE BUFFER Reagent |
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GWB-Q00222 |
GenWay Biotech |
500 ml |
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ELISA NEPTUNE BUFFER Reagent |
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GWB-Q00223 |
GenWay Biotech |
1000 ml |
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 Neptune Blocking Buffer-BB2 |
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KF17338 |
Neuromics |
500 ml |
EUR 292.8 |
 Neptune 10ul extended length barrier tip |
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BT10XLS3 |
Biotix |
10 trays of 96 / pack |
EUR 70.8 |
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Description: Low retention, Racked, Pre-Sterile, Sample Saving Surface |
 Conjugate Diluent |
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I095 |
Cygnus Technologies |
1 L |
EUR 678 |
|
|
|
Description: Conjugate Diluent by Cygnus Technologies is available in Europe via Gentaur. |
 Diluent A |
|
abx098961-6ml |
Abbexa |
6 ml |
EUR 109.2 |
|
|
 Diluent B |
|
abx098962-12ml |
Abbexa |
12 ml |
EUR 109.2 |
|
|
 HRP Diluent |
|
85-H10S |
Fitzgerald |
250 ml |
EUR 266 |
|
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Description: Dilution and stabilization buffer for monoclonal or polyclonal antibody HRP conjugates |
 IgM Diluent |
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abx090800-100l |
Abbexa |
100 µl |
EUR 575 |
IgM Diluent |
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abx090800-1ml |
Abbexa |
1 ml |
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IgM Diluent |
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abx090800-200l |
Abbexa |
200 µl |
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 ELISA diluent |
|
3652-D2 |
Mabtech AB |
2 x 120 ml |
EUR 220.5 |
 Conjugate Diluent/HRP |
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I056 |
Cygnus Technologies |
1000 ml |
EUR 678 |
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Description: Conjugate Diluent/HRP by Cygnus Technologies is available in Europe via Gentaur. |
 Rheumatoid Factor Control Diluent |
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35-RC15 |
Fitzgerald |
100 ml |
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Description: Rheumatoid Factor Control Diluent |
 Antibody Diluent |
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40125005-1 |
Glycomatrix |
100 mL |
EUR 39.08 |
Antibody Diluent |
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40125005-2 |
Glycomatrix |
500 mL |
EUR 90.23 |
Antibody Diluent |
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AR1016 |
BosterBio |
100mL (for 10000-15000 assays) |
EUR 157.2 |
 Neptune Barrier tip 10ul Extended Length Filter Tip |
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BT10XL |
Biotix |
10 trays of 96 / pack |
EUR 70.8 |
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Description: 10ul extended length barrier tip. Racked, Pre-Sterile, Natural Polypropylene. |
 OOSA09562-100ML - ELISA NEPTUNE BUFFER Accessory Reagent |
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OOSA09562-100ML |
Aviva Systems Biology |
100ml |
EUR 169 |
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 OOSA11205-500ML - ELISA NEPTUNE BUFFER Accessory Reagent |
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OOSA11205-500ML |
Aviva Systems Biology |
500ml |
EUR 519 |
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 Diluent Buffer A |
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abx296005-10ml |
Abbexa |
10 ml |
EUR 109.2 |
|
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 Sucrose Diluent 40% |
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M1749-500G |
EWC Diagnostics |
1 unit |
EUR 43.52 |
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Description: Sucrose Diluent 40% |
 ABC diluent buffer |
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AR1106-3 |
Antagene |
12ml |
EUR 150 |
|
Description: IHC |
 Assay Diluent Buffer |
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DS0231-100ML |
EWC Diagnostics |
1 unit |
EUR 3.26 |
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Description: Assay Diluent Buffer |
Assay Diluent Buffer |
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DS0231-500ML |
EWC Diagnostics |
1 unit |
EUR 15.45 |
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Description: Assay Diluent Buffer |
 TMB Substrate Diluent |
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42R-TB105 |
Fitzgerald |
1 liter |
EUR 327 |
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Description: Dilution buffer for TMB Substrate in immunoassays |
 Diluent TSB + Cap 4 |
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LQ504C-10X90ML |
EWC Diagnostics |
1 unit |
EUR 41.18 |
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Description: Diluent TSB + Cap 4 |
Diluent TSB + Cap 4 |
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LQ504CC-5X190ML |
EWC Diagnostics |
1 unit |
EUR 44.29 |
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Description: Diluent TSB + Cap 4 |
Diluent TSB + Cap 4 |
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LQ504D-5X490ML |
EWC Diagnostics |
1 unit |
EUR 63.15 |
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Description: Diluent TSB + Cap 4 |
 Diluent) Lipoprotein (a) Diluent |
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85-LD01 |
Fitzgerald |
1 G |
Ask for price |
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Description: Lipoprotein (a) deficient serum for use as a diluent in lipoprotein (a) studies |
 *Lecithin Diluent Broth |
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M1319-500G |
EWC Diagnostics |
1 unit |
EUR 48.17 |
|
Description: *Lecithin Diluent Broth |
 Standard Diluent Buffer |
|
abx098951-20ml |
Abbexa |
20 ml |
EUR 109.2 |
|
|
Weighted gene coexpression community analysis (WGCNA) was used to discover the co-expression modules and hub genes in MDD. A protein-protein interplay (PPI) community of probably the most important module and a TF-miRNA-lncRNA regulatory community of MDD have been constructed utilizing bioinformatics analysis instruments.
