Identification of key genes and pathways in scleral extracellular matrix remodeling in glaucoma: Potential therapeutic agents discovered using bioinformatics analysis

Identification of key genes and pathways in scleral extracellular matrix remodeling in glaucoma: Potential therapeutic agents discovered using bioinformatics analysis

April 19, 2021 Off By Ava Banks

Glaucoma is a number one trigger of irreversible blindness. Remodeling of the scleral extracellular matrix (ECM) performs an vital position in the event of glaucoma. The goal of this research was to determine the key genes and pathways for the ECM remodeling of sclera in glaucoma by bioinformatics analysis and to discover potential therapeutic agents for glaucoma administration. Genes related to glaucoma, sclera and ECM remodeling have been detected using the textual content mining software pubmed2ensembl, and assigned Gene Ontology (GO) organic course of phrases and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways using the GeneCodis program.

A protein-protein interplay (PPI) community was constructed by STRING and visualized in Cytoscape, module analysis was carried out using the Molecular Complex Detection (MCODE) plugin, and GO and KEGG analyses of the gene modules have been carried out using the Database of Annotation, Visualization and Integrated Discovery (DAVID) platform. The genes that clustered in the numerous module have been chosen as core genes, and features and pathways of the core genes have been visualized using ClueGO and CluePedia. Lastly, the drug-gene interplay database was used to discover drug-gene interactions of the core genes to seek out drug candidates for glaucoma.

We recognized 125 genes widespread to “Glaucoma”, “Sclera”, and “ECM remodeling” by textual content mining. Gene useful enrichment analysis yielded 30 enriched GO phrases and 20 related KEGG pathways. A PPI community that included 60 nodes with 249 edges was constructed, and three gene modules have been obtained using the MCODE. We chosen 13 genes that clustered in module 1 as core candidate genes that have been related primarily with ECM degradation and cell proliferation and division.

The HIF-1 signaling pathway, FOXO signaling pathway, PI3K-Akt signaling pathway and TGFB signaling pathway have been discovered to be enriched. We discovered that 11 of the 13 chosen genes might be focused by 26 present medicine. The outcomes confirmed that VEGFATGFB1TGFB2TGFB3IGF2IGF1EGFFN1KNG1TIMP1, SERPINE1THBS1, and VWF have been potential key genes concerned to scleral ECM remodeling. Furthermore, 26 medicine have been recognized as potential therapeutic agents for glaucoma remedy and administration.

STATegra: Multi-Omics Data Integration – A Conceptual Scheme With a Bioinformatics Pipeline

Technologies for profiling samples using completely different omics platforms have been on the forefront for the reason that human genome venture. Large-scale multi-omics information maintain the promise of deciphering completely different regulatory layers. Yet, whereas there’s a myriad of bioinformatics instruments, every multi-omics analysis seems to begin from scratch with an arbitrary resolution over which instruments to make use of and the way to mix them. Therefore, it’s an unmet must conceptualize the way to combine such information and implement and validate pipelines in completely different circumstances.

We have designed a conceptual framework (STATegra), aiming it to be as generic as potential for multi-omics analysis, combining accessible multi-omic anlaysis instruments (machine studying element analysis, non-parametric information mixture, and a multi-omics exploratory analysis) in a step-wise method. While in a number of research, we’ve got beforehand mixed these integrative instruments, right here, we offer a scientific description of the STATegra framework and its validation using two The Cancer Genome Atlas (TCGA) case research. For each, the Glioblastoma and the Skin Cutaneous Melanoma (SKCM) circumstances, we reveal an enhanced capability of the framework (and past the person instruments) to determine options and pathways in comparison with single-omics analysis.

Such an integrative multi-omics analysis framework for figuring out options and elements facilitates the invention of new biology. Finally, we offer a number of choices for making use of the STATegra framework when parametric assumptions are fulfilled and for the case when not all of the samples are profiled for all omics. The STATegra framework is constructed using a number of instruments, that are being built-in step-by-step as OpenSource in the STATegRa Bioconductor package deal.

Identification of key genes and pathways in scleral extracellular matrix remodeling in glaucoma: Potential therapeutic agents discovered using bioinformatics analysis

Identification of Pivotal MicroRNAs and Target Genes Associated with Persistent Atrial Fibrillation Based on Bioinformatics Analysis

Atrial fibrillation (AF) is one of the most typical supraventricular arrhythmias worldwide. However, the particular molecular mechanism underlying AF stays unclear. Our research is geared toward figuring out pivotal microRNAs (miRNAs) and concentrating on genes related to persistent AF (pAF) using bioinformatics analysis. Three gene expression array datasets and an miRNA expression array dataset (GSE68475) related to pAF have been downloaded. Differentially expressed genes (DEGs) have been recognized using the LIMMA package deal, and differentially expressed miRNAs (DEMs) have been screened from GSE68475.

Target genes for DEMs have been predicted using the miRTarBase database, and intersections between these goal genes and DEGs have been chosen for additional analysis, together with the technology of protein-protein interplay (PPI) community, miRNA-transcription factor-target regulatory community, and drug-gene community. A complete of 264 DEGs and 40 DEMs have been recognized between the pAF and management teams. Functional and pathway enrichment analyses of up- and downregulated DEGs have been carried out. The widespread genes (CGs) have been primarily enriched in the phosphoinositide 3-kinase- (PI3K-) protein kinase B (Akt) signaling pathway, unfavourable regulation of cell division, and response to hypoxia.

Bead Sample Pack - 5M Set

BSP-5Y 1pack
EUR 241
Description: Bead sample pack for Bullet Blender 5mL Storm models. Includes 10mL of: ZROB015, ZROB05, ZROB20, SSB02, SSB14B, SSB32, SSB60, SSB110 and SSUFO35.

Bead Sample Pack - Full Set

BSP-ALL2 1pack
EUR 384
Description: Bead sample pack inlcudes sampling of all 20 bead types in 10mL tubes.

Bead Sample Pack - Cell Cultures

BSP-CC2 1pack
EUR 195
Description: Bead sample pack for homogenization of cell cultures. Includes 10mL of: GB01, GB05, ZROB015, ZROB05 and SSB02.

Bead Sample Pack - Microcentrifuge Set

BSP-MC2 1pack
EUR 232
Description: Bead sample pack for Bullet Blender 1.5mL tube models. Includes 10mL of: ZROB015, ZROB05, ZROB10, ZROB20, SSB02, SSB14B, SSB32 and SSUFO35.

All Sample Diluents Sample Pack

KF17355 3X100 ml
EUR 272

Red Blood Cell Sample Pack

88R-1050 6 x 2 ml
EUR 403
Description: Horse, Mouse, Rabbit, Sheep, Bovine and Chicken glutaraldehyde stabilized blood cell samples

TMB Peroxidase Substrate SAMPLE PACK

42R-TB101 3 x 100 ml
EUR 300
Description: 100mL of 3 different TMB Peroxidase Substrates ready to use in immunoassays: Ultra sensitivite, Highly Sensitive, and Slow Acting.

3 Blocking Buffer Sample Pack

KF17340 3 x 100 ml
EUR 205

All Assay Diluents Sample Pack

KF17351 4X100 ml
EUR 272

Exosome isolation Solution - Serum/ Plasma (easy version of P101, 95% pure exosome) sample

P101EZ--sample NULL
EUR 0

Exosome isolation Solution - Cell Media/ Urine (easy version of P100, 95% pure exosome) sample

P100EZ-sample NULL
EUR 0

Micro Bead Sterlizer

B1201-E 1 PC
EUR 542.7
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Micro Bead Sterlizer

B1202-E 1 PC
EUR 84.14
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Refill Glass Beads

B1201-BEAD 1 PC
EUR 117.78
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

turboscan software densitometer

EHCA1200-SOFT ea
EUR 2744

Column Packing Kit

PACK-KIT 1pack
EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

Sample Diluent

I094 1000 ml
EUR 519
  • Product category: Buffer solution
Description: Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Sample Diluent

I094-100 100 ml
EUR 211
  • Product category: Buffer solution
Description: Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Sample Diluent

I094-500 500 ml
EUR 373
  • Product category: Buffer solution
Description: Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Bangs Lab Bead Solution

SOLN1-1000 1000 ML
EUR 155.06
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres

Bangs Lab Bead Solution

SOLN1-2000 2000 ML
EUR 212.7
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres

Bangs Lab Bead Solution

SOLN1-500 500 ML
EUR 98.51
Description: Bangs Lab Bead Solution is ready-to-use solution and is suitable for dilution and/or storage of plain, dyed, or functionalized polymer microspheres

Adapter pack

C1005-AC2 1 PC
EUR 98.5
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Adapter pack

C3100-ADP 1 PC
EUR 164.18
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

EZ Pack

A2501 1 PC
EUR 365.66
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

EZ Pack

A2505 1 PC
EUR 183.03
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Collagel Hydrogel Soft-Rat

CGH321 20ml
EUR 271

Collagel Hydrogel Soft+-Rat

CGH322 20ml
EUR 284

Collagel Hydrogel Soft-Bovine

CGHB321 20ml
EUR 362

Collagel Hydrogel Soft+-Bovine

CGHB322 20ml
EUR 388

Collagel Hydrogel Soft-Human

CGHH321 20ml
EUR 623

Collagel Hydrogel Soft+-Human

CGHH322 20ml
EUR 636

Sample diluent buffer

AR1106-1 30ml
EUR 91

BSA Sample Diluent

F031A 1000 ml
EUR 488
  • Product category: Buffer solution
Description: BSA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

BSA Sample Diluent

F031A-100 100 ml
EUR 195
  • Product category: Buffer solution
Description: BSA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

BSA Sample Diluent

F031A-500 500 ml
EUR 411
  • Product category: Buffer solution
Description: BSA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Sample Denaturing Buffer

F054 12 ml
EUR 195
  • Product category: Buffer solution
Description: Sample Denaturing Buffer by Cygnus Technologies is available in Europe via Gentaur.

Sample Treatment Buffer

F175 1000 ml
EUR 411
  • Product category: Buffer solution
Description: Sample Treatment Buffer by Cygnus Technologies is available in Europe via Gentaur.

Sample Treatment Buffer

F175-100 100 ml
EUR 219
  • Product category: Buffer solution
Description: Sample Treatment Buffer by Cygnus Technologies is available in Europe via Gentaur.

Sample Treatment Plate

F402 1x 96 wells plate
EUR 103
  • Product category: Microplates
Description: Sample Treatment Plate by Cygnus Technologies is available in Europe via Gentaur.

ELISA Sample Diluent

ESD125 125 ml
EUR 80

ELISA Sample Diluent

ESD500 500 ml
EUR 109

ELISA Sample Diluent

ESD999 1000 ml
EUR 157

Sample Diluent Buffer

I028-100 100 ml
EUR 211
  • Product category: Buffer solution
Description: Sample Diluent Buffer by Cygnus Technologies is available in Europe via Gentaur.

Sample Diluent Buffer

I028-1000 1000 ml
EUR 519
  • Product category: Buffer solution
Description: Sample Diluent Buffer by Cygnus Technologies is available in Europe via Gentaur.

Sample Diluent Buffer

I028-500 500 ml
EUR 373
  • Product category: Buffer solution
Description: Sample Diluent Buffer by Cygnus Technologies is available in Europe via Gentaur.

HEPES Sample Diluent

I050 1000 ml
EUR 527
  • Product category: Buffer solution
Description: HEPES Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

HEPES Sample Diluent

I050-100 100 ml
EUR 219
  • Product category: Buffer solution
Description: HEPES Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

HEPES Sample Diluent

I050-500 500 ml
EUR 334
  • Product category: Buffer solution
Description: HEPES Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Sample Diluent Buffer

abx296001-20ml 20 ml
EUR 91
  • Shipped within 5-10 working days.

DNA Sample Diluent

D006-100 100 ml
EUR 373
  • Product category: Buffer solution
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

DNA Sample Diluent

D006-1000 1000 ml
EUR 1167
  • Product category: Buffer solution
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

DNA Sample Diluent

D006-500 500 ml
EUR 726
  • Product category: Buffer solution
Description: DNA Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Rotavirus Positive Sample

DAG-H10377 1 ml dry ice
EUR 1105

RSV Positive Sample

DAG-H10378 1 ml dry ice
EUR 1105

Sample Diluent, 60ML

X028-60ML 60ML
EUR 143

Protein A Tell-Tale Gold Ribbon Sample Pack, 3 x (1 cm x 30 cm)

TTGA-SP3-B090 3 x (1 cm x 30 cm)
EUR 227.67
  • Product Category: Gold Ribbon
Description: The pack contains polyester ribbon, which is soaked with 0.13 O.D./cm2 concentration with Protein G conjugated to gold nanoparticles.

Protein G Tell-Tale Gold Ribbon Sample Pack, 3 x (1 cm x 30 cm)

TTGG-SP3-B090 3 x (1 cm x 30 cm)
EUR 227.67
  • Product Category: Gold Ribbon
Description: The pack contains polyester ribbon, which is soaked with 3 different concentrations with Protein G conjugated to gold nanoparticles.

DEAE Rapid Run Agarose Bead

DEAERR-25 25 ml
EUR 102

DEAE Rapid Run Agarose Bead

DEAERR-300 300 ml
EUR 492

CM Rapid Run Agarose Bead

CMRR-25 25 ml
EUR 102

CM Rapid Run Agarose Bead

CMRR-300 300 ml
EUR 492

SP Rapid Run Agarose Bead

SPRR-25 25 ml
EUR 102

SP Rapid Run Agarose Bead

SPRR-300 300 ml
EUR 492

Protein A/G Tell-Tale Gold Ribbon Sample Pack, 3 x (1 cm x 30 cm)

TTGAG-SP3-B090 3 x (1 cm x 30 cm)
EUR 227.67
  • Product Category: Gold Ribbon
Description: The pack contains polyester ribbon, which is soaked with 3 different concentrations with Protein A and G conjugated to gold nanoparticles.

0.2ml Adapter pack

C1008-A2-6 1 PC
EUR 84.94
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

0.2ml Adapter pack

C1008-A2-9 1 PC
EUR 395.96
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

0.5ml Adapter pack

C1008-A5-6 1 PC
EUR 80.95
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

0.5ml Adapter pack

C1008-A5-8 1 PC
EUR 84.94
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Safe-Pack™

G108-P G108-WGR
EUR 104

mini cooling pack

EVS1100-COOL ea
EUR 48

maxi cooling pack

EVS1300-COOL ea
EUR 82

Replacement generator pack

D1000-M5 1 PC
EUR 531.32
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Replacement generator pack

D1000-M7 1 PC
EUR 415.61
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Spatulas (Large Pack)

SPAT1 50pack
EUR 301
Description: Individually wrapped spatulas. RNase/DNase free, non-pyrogenic, antistatic, sterile, plastic. Pack of 50.

Spatulas (Small Pack)

SPAT2 10pack
EUR 133
Description: Individually wrapped spatulas. RNase/DNase free, non-pyrogenic, antistatic, sterile, plastic. Pack of 10.

Total RNA ExtractionMini KitAnimal Tissues

FYG301-50P 50 Preps Ask for price

Total RNA ExtractionMini KitAnimal Tissues

FYG302-100P 100 Preps Ask for price

Total RNA ExtractionMini KitAnimal Tissues

FYG302-300P 300 Preps Ask for price

Total RNA ExtractionMini KitPlant Tissues

FYG303-100P 100 Preps Ask for price

Total RNA ExtractionMini KitPlant Tissues

FYG303-300P 300 Preps Ask for price

Total RNA ExtractionMini KitPlant Tissues

FYG303-50P 50 Preps Ask for price

flatbed scanner for ehca110-soft

EHCA1200-SCAN ea
EUR 496

SP2/0 Sample Diluent

F183A 1000 ml
EUR 835
  • Product category: Buffer solution
Description: SP2/0 Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

SP2/0 Sample Diluent

F183A-100 100 ml
EUR 257
  • Product category: Buffer solution
Description: SP2/0 Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

SP2/0 Sample Diluent

F183A-500 500 ml
EUR 488
  • Product category: Buffer solution
Description: SP2/0 Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat IgG Sample Diluent

F213A 1000 ml
EUR 565
  • Product category: Buffer solution
Description: Goat IgG Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat IgG Sample Diluent

F213A-100 100 ml
EUR 257
  • Product category: Buffer solution
Description: Goat IgG Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat IgG Sample Diluent

F213A-500 500 ml
EUR 411
  • Product category: Buffer solution
Description: Goat IgG Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

NS/0 Sample Diluent

F223A 1000 ml
EUR 835
  • Product category: Buffer solution
Description: NS/0 Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

NS/0 Sample Diluent

F223A-100 100 ml
EUR 257
  • Product category: Buffer solution
Description: NS/0 Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

NS/0 Sample Diluent

F223A-500 500 ml
EUR 488
  • Product category: Buffer solution
Description: NS/0 Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

A549 Sample Diluent, 100mL

F233A-100 100 ml
EUR 257
  • Product category: Buffer solution
Description: A549 Sample Diluent, 100mL by Cygnus Technologies is available in Europe via Gentaur.

A549 Sample Diluent, 500mL

F233A-500 500 ml
EUR 411
  • Product category: Buffer solution
Description: A549 Sample Diluent, 500mL by Cygnus Technologies is available in Europe via Gentaur.

comb 10 sample, 0.8mm

EVS3100-C10-0.8 ea
EUR 59

comb 10 sample, 1.5mm

EVS3100-C10-1.5 ea
EUR 59

comb 12 sample, 0.8mm

EVS3100-C12-0.8 ea
EUR 59

comb 12 sample, 1.5mm

EVS3100-C12-1.5 ea
EUR 59

comb 6 sample, 0.8mm

EVS3100-C6-0.8 ea
EUR 59

comb 6 sample, 1.5mm

EVS3100-C6-1.5 ea
EUR 59

comb 8 sample, 0.8mm

EVS3100-C8-0.8 ea
EUR 59

comb 8 sample, 1.5mm

EVS3100-C8-1.5 ea
EUR 59

comb 10 sample, 0.8mm

EVS3200-C10-0.8 ea
EUR 65

comb 10 sample, 1.5mm

EVS3200-C10-1.5 ea
EUR 65

comb 15 sample, 0.8mm

EVS3200-C15-0.8 ea
EUR 65

comb 15 sample, 1.5mm

EVS3200-C15-1.5 ea
EUR 65

comb 20 sample, 0.8mm

EVS3200-C20-0.8 ea
EUR 65

comb 20 sample, 1.5mm

EVS3200-C20-1.5 ea
EUR 65

comb 25 sample, 0.8mm

EVS3200-C25-0.8 ea
EUR 65

comb 25 sample, 1.5mm

EVS3200-C25-1.5 ea
EUR 65

comb 10 sample, 0.8mm

EVS3300-C10-0.8 ea
EUR 65

comb 10 sample, 1.5mm

EVS3300-C10-1.5 ea
EUR 65

comb 15 sample, 0.8mm

EVS3300-C15-0.8 ea
EUR 65

comb 15 sample, 1.5mm

EVS3300-C15-1.5 ea
EUR 65

comb 20 sample, 0.8mm

EVS3300-C20-0.8 ea
EUR 65

comb 20 sample, 1.5mm

EVS3300-C20-1.5 ea
EUR 65

comb 25 sample, 0.8mm

EVS3300-C25-0.8 ea
EUR 65

comb 25 sample, 1.5mm

EVS3300-C25-1.5 ea
EUR 65

CometAssay HT Sample Kit

4252-040-K 40 Tests
EUR 428

Deproteinizing Sample Preparation Kit

55R-1542 200 assays
EUR 450
Description: Deproteinizing Sample Preparation Kit for use in the research laboratory

Salivary Sample Collection Kit

55R-IB76305 500 tests
EUR 301
Description: Salivary sample collection kit for the detection of free Salivary proteins and enzymes in the research laboratory

Deproteinizing Sample Preparation Kit

K2184-200 200 assays
EUR 321

ProtoGel Sample Prep Kit

NAT1248 EACH
EUR 186

Deproteinizing Sample Preparation Kit

K808-200
EUR 338

Neptune Sample Diluent-SD3

KF17354 500 ml
EUR 244

RoomTemp Sample Lysis Kit

P073-01 250 rxn (5 ml)
EUR 212

RoomTemp Sample Lysis Kit

P073-02 1000 rxn ( 20 ml)
EUR 473

RoomTemp Sample Lysis Kit

P073-03 5000 rxn (100 ml)
EUR 1400

Inactivated ADV Positive Sample

VAng-Lsx0001-inquire inquire Ask for price
Description: ADV Positive Sample, natural antigen.

Recombinant RSV Positive Sample

VAng-Lsx0452-inquire inquire Ask for price
Description: RSV Positive Sample.

Coronavirus Sample Preparation Solution

M1461-50 50 ml Ask for price

Hemoglobin Sample Diluent, 50ML

X052-50ML 50ML
EUR 153

Sample Diluent (Conc.), 12ML

X074-12ML 12ML
EUR 123

Sample Diluent (Conc.), 60ML

X074-60ML 60ML
EUR 143

Anti-DDK(FLAG) Agarose bead Conjugated

D4501-001 1ml
EUR 550

Anti-DDK(FLAG) Agarose bead Conjugated

D4501-005 5ml
EUR 1373

Nickel NTA Magnetic Agarose Bead (5%)

MagNTANi5-10 10ml suspension
EUR 284

Nickel NTA Magnetic Agarose Bead (5%)

MagNTANi5-2 2ml suspension
EUR 99

The PPI community, miRNA-transcription factor-target regulatory community, and drug-gene community have been constructed using Cytoscape. The current research revealed a number of novel miRNAs and genes concerned in pAF. We speculated that miR-4298, miR-3125, miR-4306, and miR-671-5p may signify important miRNAs that act on the goal gene superoxide dismutase 2 (SOD2) in the course of the improvement of pAF and might function important biomarkers for pAF analysis and remedy. Moreover, MYC may operate in pAF pathogenesis by means of the PI3K-Akt signaling pathway.